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Test Code CHAL or LAB2151 Childhood Allergy Panel, Serum

Important Note

If the Respiratory Allergen Profile is requested with the Childhood Allergy Profile, please order the following: 

If the Food Allergen Panel is requested with the Childhood Allergy Panel, please order the following:

  • CHAL (LAB2151) for the Childhood Allergy Panel
  • FALADD (LAB2570) for Additional Allergens included within the Food Allergy Panel.

Please note:  If the whole allergen for Peanut, Milk, or Egg is positive, the corresponding allergen component profile below is reflex ordered to provide additional diagnostic information.

Profile Information

Test ID Reporting Name Available Separately? Always Performed?
ALTAL IgE Alternaria Y Y
CATAL IgE Cat Dander Y Y
CEDAL IgE Red Cedar Y Y
CLADAL IgE Cladosporium Y Y
DMFAL IgE Dust Mite (DF) Y Y
DMPAL IgE Dust Mite (DP) Y Y
DOGAL IgE Dog Dander Y Y
RCHAL IgE Cockroach Y Y
CODAL IgE Codfish Y Y
EGGAL IgE Egg White Y Y
MILKAL IgE Milk Y Y
PEAAL IgE Peanut Y Y
SOYAL IgE Soybean Y Y
SRMPAL IgE Shrimp Y Y
WALAL IgE Walnut Nut Y Y
WHEAL IgE Wheat Y Y
MOUSUA IgE Mouse Urine Y Y
TIGE Total IgE Y Y

Specimen Requirements

Container Type:

Optimal: Gold

Acceptable: Red 

 
Optimal Collection Volume: 

5 mL full tube
Minimum Volume:

4 mL
Collection Instructions:

Gently invert the sample 5-6 times after collection.
Specimen Transport:

Refrigerate
Processing Instructions: 

1. Allow the specimen to clot for 30 minutes.

2. Centrifuge specimen within 2 hours of collection.

3. After centrifugation, specimen tubes without a gel barrier should have the serum aliquoted to a false bottom container.

4. Keep serum refrigerated until testing can be performed.

Specimen Stability

Specimen Type Temperature Time
Serum Refrigerated 7 days
Room Temperature 24 hours

Specimen Rejection Criteria

Quantity not sufficient

Useful For

Determining a diagnosis of an allergy to one or more childhood allergens (see profile information).

Methodology

Phadia ImmunoCAP - Fluorescence enzyme immunoassay

Reference Ranges

The normal range for Total Serum IgE represents 1 SD* (Standard Deviation) for that particular age group in the population. Serum IgE levels greater than 1 SD suggest the presence of allergic disease. Serum IgE levels greater than 2 SD* strongly suggest the presence of allergic disease. 

*The SD ranges are dependent on the age of the patient. Please reference the table below for age-specific 1 and 2 SD ranges.

Total IgE - Grouped by Age
Age Mean (kU/L)  +1SD (kU/L)  +2SD (kU/L)
0-6 weeks 0.6   2.3   4.0
7 weeks-3 months 1.0   4.1   7.2
4-6 months 1.8   7.3   13.0
7-9 months 2.6   10.0   17.0
10-23 months 3.2   13.0   23.0
2 years 5.7   23.0   40.0
3 years 8.0   32.0   56.0
4 years 10.0   40.0   70.0
5 years 12.0   48.0   84.0
6 years 14.0   56.0   98.0
7 years 16.0   63.0   110.0
8 years 18.0   71.0   124.0
9 years 20.0   78.0   136.0
10 years 22.0   85.0   148.0
Adults 3.2   41.0  69.0

After peaking at 10 years, serum total IgE levels decline to adult values.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Specific IgE - All Ages
Value (kU/L) Interpretation Class
< 0.10 Negative Negative
0.10 - 0.35 Equivocal/Very Low Class 0/1
0.36 - 0.70 Low level of allergy, indicative of ongoing sensitization Class 1
0.71 - 3.50 Moderate level of allergy, indicative of stronger ongoing sensitization Class 2
3.51 - 17.50 High level of allergy, indicative of high-level sensitization Class 3
17.51 - 50.00 Very high level of allergy, indicative of very high-level sensitization Class 4
50.01 - 100.00 Very high level of allergy, indicative of very high-level sensitization Class 5
> 100.00 Very high level of allergy, indicative of very high-level sensitization Class 6

Interpretive

Total IgE

Elevated concentrations of total immunoglobulin E (IgE) may be found in various clinical diseases, including allergic disease, certain primary immunodeficiencies, infections, inflammatory diseases, and malignancies.

 

Elevated total IgE concentrations may be consistent with a diagnosis of allergic bronchopulmonary aspergillosis, provided other laboratory and clinical criteria are fulfilled.

 

Specific IgE

Positive results indicate the possibility of allergic disease.

 

Negative results may rule out allergy, except in rare cases of allergic disease induced by exposure to a single allergen.

 

Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be responsible for eliciting signs and symptoms.

 

The level of IgE antibodies in serum varies directly with the concentration of IgE antibodies expressed as a class score or kU/L.

 

Source: Mayo Clinical Labs

Day(s) Performed

Monday through Friday

Expected TAT

Same day or 1-3 days

Performing Laboratory

Bronson Laboratory, Chemistry - Kalamazoo

Sample Retention Time

7 days

CPT Code

  • 86003 per allergen
  • 82785 - Total IgE