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HelpTest Code RSAL or LAB2259 Respiratory Allergy Profile, Serum
Profile Information
| Test ID | Reporting Name | Available Separately? | Always Performed? |
|---|---|---|---|
| ALTAL | IgE Alternaria | Y | Y |
| APRGAL | IgE Aspergillus | Y | Y |
| ASHAL | IgE White Ash | Y | Y |
| BERGAL | IgE Bermuda Grass | Y | Y |
| CATAL | IgE Cat Dander | Y | Y |
| CEDAL | IgE Red Cedar | Y | Y |
| CLADAL | IgE Cladosporium | Y | Y |
| COTAL | IgE Cottonwood | Y | Y |
| DMFAL | IgE Dust Mite (DF) | Y | Y |
| DMPAL | IgE Dust Mite (DP) | Y | Y |
| DOGAL | IgE Dog Dander | Y | Y |
| MULBAL | IgE Mulberry | Y | Y |
| NETAL | IgE Nettle | Y | Y |
| PENIAL | IgE Penicillium | Y | Y |
| RCHAL | IgE Cockroach | Y | Y |
| THISAL | IgE Russian Thistle | Y | Y |
| TIMAL | IgE Timothy Grass | Y | Y |
| BRCHAL | IgE Birch | Y | Y |
| ELMAL | IgE Elm | Y | Y |
| MAPLE | IgE Red Maple | Y | Y |
| MARSAL | IgE Rough Marsh Elder | Y | Y |
| OAKAL | IgE Oak | Y | Y |
| RAGAL | IgE Ragweed (Short/Common) | Y | Y |
| MOUSUA | IgE Mouse Urine | Y | Y |
| TIGE | Total IgE | Y | Y |
Specimen Requirements
| Container Type: |
Optimal: Gold Acceptable: Red
|
| Optimal Collection Volume: |
4.5mL; full tube |
| Minimum Volume: |
3 mL |
| Collection Instructions: |
Gently invert the sample 5-6 times after collection. |
| Specimen Transport: |
Refrigerate |
| Processing Instructions: |
1. Allow the specimen to clot for 30 minutes. 2. Centrifuge specimen within 2 hours of collection. 3. After centrifugation, specimen tubes without a gel barrier should have the serum aliquoted to a false bottom container. 4. Keep serum refrigerated until testing can be performed. |
Specimen Stability
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated | 7 days |
| Room Temperature | 24 hours |
Specimen Rejection Criteria
Quantity not sufficient
Useful For
Determining a diagnosis of an allergy to one or more respiratory allergens (see profile information).
Methodology
Phadia ImmunoCAP - Fluorescence enzyme immunoassay
Reference Ranges
The normal range for Total Serum IgE represents 1 SD* (Standard Deviation) for that particular age group in the population. Serum IgE levels greater than 1 SD suggest the presence of allergic disease. Serum IgE levels greater than 2 SD* strongly suggest the presence of allergic disease.
*The SD ranges are dependent on the age of the patient. Please reference the table below for age-specific 1 and 2 SD ranges.
| Total IgE - Grouped by Age | |||
|---|---|---|---|
| Age | Mean (kU/L) | +1SD (kU/L) | +2SD (kU/L) |
| 0-6 weeks | 0.6 | 2.3 | 4.0 |
| 7 weeks-3 months | 1.0 | 4.1 | 7.2 |
| 4-6 months | 1.8 | 7.3 | 13.0 |
| 7-9 months | 2.6 | 10.0 | 17.0 |
| 10-23 months | 3.2 | 13.0 | 23.0 |
| 2 years | 5.7 | 23.0 | 40.0 |
| 3 years | 8.0 | 32.0 | 56.0 |
| 4 years | 10.0 | 40.0 | 70.0 |
| 5 years | 12.0 | 48.0 | 84.0 |
| 6 years | 14.0 | 56.0 | 98.0 |
| 7 years | 16.0 | 63.0 | 110.0 |
| 8 years | 18.0 | 71.0 | 124.0 |
| 9 years | 20.0 | 78.0 | 136.0 |
| 10 years | 22.0 | 85.0 | 148.0 |
| Adults | 3.2 | 41.0 | 69.0 |
|
After peaking at 10 years, serum total IgE levels decline to adult values. |
|||
| Specific IgE - All Ages | ||
|---|---|---|
| Value (kU/L) | Interpretation | Class |
| < 0.10 | Negative | Negative |
| 0.10 - 0.35 | Equivocal/Very Low | Class 0/1 |
| 0.36 - 0.70 | Low level of allergy, indicative of ongoing sensitization | Class 1 |
| 0.71 - 3.50 | Moderate level of allergy, indicative of stronger ongoing sensitization | Class 2 |
| 3.51 - 17.50 | High level of allergy, indicative of high-level sensitization | Class 3 |
| 17.51 - 50.00 | Very high level of allergy, indicative of very high-level sensitization | Class 4 |
| 50.01 - 100.00 | Very high level of allergy, indicative of very high-level sensitization | Class 5 |
| > 100.00 | Very high level of allergy, indicative of very high-level sensitization | Class 6 |
Interpretive
Total IgE
Elevated concentrations of total immunoglobulin E (IgE) may be found in various clinical diseases, including allergic disease, certain primary immunodeficiencies, infections, inflammatory diseases, and malignancies.
Elevated total IgE concentrations may be consistent with a diagnosis of allergic bronchopulmonary aspergillosis, provided other laboratory and clinical criteria are fulfilled.
Specific IgE
Positive results indicate the possibility of allergic disease.
Negative results may rule out allergy, except in rare cases of allergic disease induced by exposure to a single allergen.
Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be responsible for eliciting signs and symptoms.
The level of IgE antibodies in serum varies directly with the concentration of IgE antibodies expressed as a class score or kU/L.
Source: Mayo Clinical Labs
Day(s) Performed
Monday through Friday
Expected TAT
Same day or 1-3 days
Performing Laboratory
Bronson Laboratory, Chemistry - Kalamazoo
Sample Retention Time
7 days
CPT Code
- 86003 per allergen
- 82785 - Total IgE