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Test Code PNUTCP or LAB3553 IgE Peanut Component Allergen Panel, Serum

Important Note

Please note: If the whole allergen for Peanut (LAB592) is positive, the IgE Peanut Component Panel is reflex ordered to provide additional diagnostic information.

Profile Information

Test ID Reporting Name  Available Separately? Always Performed?
PEEAL IgE Peanut Y Y
PNUTH1 IgE Peanut ARA H1 N Y
PNUTH2 IgE Peanut ARA H2 N Y
PNUTH3 IgE Peanut ARA H3 N Y
PNUTH6 IgE Peanut ARA H6 N Y
PNUTH8 IgE Peanut ARA H8 N Y
PNUTH9 IgE Peanut ARA H9 N Y

Note: An interpretive comment is also provided.

Specimen Requirements

Container Type:

Optimal: Gold

Acceptable: Red 

 
Optimal Collection Volume: 

4.5mL; full tube
Minimum Volume:

3 mL
Collection Instructions:

Gently invert the sample 5-6 times after collection.
Specimen Transport:

Refrigerate
Processing Instructions: 

1. Allow the specimen to clot for 30 minutes.

2. Centrifuge specimen within 2 hours of collection.

3. After centrifugation, specimen tubes without a gel barrier should have the serum aliquoted to a false bottom container.

4. Keep serum refrigerated until testing can be performed.

Specimen Stability

Specimen Type Temperature Time
Serum Refrigerated 7 days
Room Temperature 24 hours

Specimen Rejection Criteria

Quantity not sufficient

Useful For

Determining a diagnosis of an allergy to peanut components Ara h 8, 9, 1, 2, 3, and 6. 

Methodology

Phadia ImmunoCAP - Fluorescence enzyme immunoassay

Reference Ranges

Specific IgE - All Ages
Value (kU/L) Interpretation Class
< 0.10 Negative Negative
0.10 - 0.35 Equivocal/Very Low Class 0/1
0.36 - 0.70 Low level of allergy, indicative of ongoing sensitization Class 1
0.71 - 3.50 Moderate level of allergy, indicative of stronger ongoing sensitization Class 2
3.51 - 17.50 High level of allergy, indicative of high-level sensitization Class 3
17.51 - 50.00 Very high level of allergy, indicative of very high-level sensitization Class 4
50.01 - 100.00 Very high level of allergy, indicative of very high-level sensitization Class 5
> 100.00 Very high level of allergy, indicative of very high-level sensitization Class 6

Interpretive

The finding of a positive “whole” antibody is important in identifying patients sensitized to particular foods. Subsequent food allergen component testing can provide additional information useful for patient management. Component testing results may also be used by an allergist/specialist to determine if an oral food challenge is appropriate.

 

Characteristics of the IgE Peanut Component Panel are described in the table below.

 

Allergen Characteristics
Peanut (whole)
  • It may predict the likelihood of peanut sensitivity but may not be solely predictive of reactions or allergic response
  • 78% of patients sensitized to peanuts may not be at risk for a systemic reaction
Ara h 8 (component)
  • Lower risk of systemic reaction
  • Risk of mild, localized symptoms such as itching or tingling of the lips, mouth, and oropharynx
  • Cross-reactive with pollens, such as the birch tree
  • The patient likely is not restricted to peanut-free zones
Ara h 9 (component)
  • Variable risk of systemic reaction
  • Often accompanied by sensitization to other peanut proteins
  • Cross-reactive with fruits containing pits, such as peaches
  • There is patient variability regarding restrictions to peanut-free zones
Ara h 1, 2, 3, 6 (components)
  • Higher risk of systemic reactions, including anaphylaxis
  • Family, colleagues, and teachers should be aware of the patient's peanut allergy and have a plan. The prescription of epinephrine auto-injector should also be considered
  • Should choose peanut-free zones for the patient's safety

 

Further information can be found here: PEANT - Clinical & Interpretive: Peanut, IgE with Reflex to Peanut Components, IgE, Serum (mayocliniclabs.com)

Day(s) Performed

Monday through Friday

Expected TAT

Same day or 1-3 days

Performing Laboratory

Bronson Laboratory, Chemistry - Kalamazoo

Sample Retention Time

7 days

CPT Code

  • 86003 - whole allergen
  • 86008 - per component