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Test Code TTIM, TTIMI Thrombin Time, Plasma

Additional Codes

Epic Order Code: LAB324
Sunquest Order Code: TTIM

PLEASE NOTE: Test code TTIMI is not orderable separately and is only available when reflexed in Inhibitor/Lupus Anticoagulant Panel (INMIX).

Specimen Required

Container Type:

Optimal:  1.8 mL blue top citrate tubes

Acceptable: 2.7 mL blue top citrate tubes

 
Optimal Collection Volume: 

Tube must be filled to proper level as indicated by opaque
line etched on each blue-top tube. Volume of blood is 2.7
mL in full draw (solid, light-blue top) or 1.8 mL for partial draw (clear and blue top). Do not underfill.
Collection Instructions:

1. Do not draw from an arm with a heparin lock.

2. If collected through a blood collection set (butterfly),
a discard tube must first be drawn to eliminate dead space from tubing. 

3. Gently invert 5 to 10 times to mix blood.

4. Causes for rejection include tube under filled, clotted specimen, or sample not processed and frozen within 4 hours of collection.
Processing Instructions: 

1. Centrifuge samples in a centrifuge verifed to produce platelet poor plasma.

2. Remove plasma using platelet poor plasma technique.   

3. Aliquot each blue top tube into its own vial.  Do not pool.

4. Platelet poor plasma must be processed and frozen with 4 hours of collection.

 

Useful For

The main utility of the thrombin time test is to detect or exclude the presence of heparin or heparin-like anticoagulants which act by enhancing antithrombin's inhibition of thrombin and other procoagulant enzymes.

Profile Information

Test ID   Reporting Name Available Separately Always Performed
TTIM Thrombin Time Yes Yes
TTIMI Reflexed Thrombin Time No No

Method Name

The Thrombin TIme is a clot based assay performed on the IL ACL Top 500.

Stability Information

Specimen Type Temperature Time
Platelet Poor Plasma Ambient  4 hours
Platelet Poor Plasma Frozen -20C 2 weeks

Rejection Due To

Hemolysis Mild OK; Moderate OK; Gross Reject
Lipemia Mild OK; Moderate OK; Gross Reject
Icterus Mild OK; Moderate OK; Gross Reject
Other Clotted specimen, tube not filled to line

 

Specimen Minimum Volume

Collecting minimum volumes can result in a need for sample recollection, and/or a delay in results. Minimum volumes are subjective and cannot account for all aspects of specimen and testing needs. Refer to the Specimen Required section for optimal volumes for laboratory specimens. Contact the Bronson Laboratory if complex collection exceptions occur that require more information.

 

Minimum Volume:

Tube must be filled to line.  1.8 mL whole blood in 1 light blue top tube.
Neonate Volume: Tube must be filled to line.  1.8 mL whole blood in 1 light blue top tube.

Performing Laboratory

Bronson Laboratory, Coagulation-Kalamazoo

Day(s) Performed

Monday/Wednesday/Friday Day shift

If ordered STAT, testing performed 24/7

Reference Values

 Test ID   Reference Range    Units      
TTIM 10.3-16.6 seconds
     

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TTIM Thrombin Time 3243-3

CPT Code Information

85670

Sample Retention Time

24 hours

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