Methodology

Immunofixation

Includes identification of monoclonal gammopathies and
pathologist interpretation.

Immunofixation electrophoresis of serum is most often ordered to evaluate a monoclonal globulin detected in protein electrophoresis or to delineate a possible lymphoproliferative process, particularly myeloma. This procedure will characterize the specific light- and heavy-chain components of a monoclonal protein. The pathologist may order quantitative immunoglobulins to further evaluate any monoclonal protein detected.