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Test Code PLVX P2Y12 Platelet Reactivity Assay, Blood

Important Note

Due to transport time limitations and sample requirements, this test can only be collected at one of the main campus draw sites listed below.

Collection Location Available Collection Times
Bronson Methodist Hospital- Outpatient Testing

M-F 0700-1800

Sat 0800-1200
Bronson Battle Creek Hospital- Outpatient Testing M-F 1000-1300
Bronson LakeView Hospital- Outpatient Testing M-F 1130-1300
Bronson South Haven Hospital- Outpatient Testing M-F 1130-1345

***SEND AMBIENT WITHIN 3 HOURS***

Test must be collected using 1.8 mL size BD or 2.0 mL size Greiner sodium citrate tubes. (Do not collect 2.7mL size Tubes.)

Additional Codes

Epic Order Code: LAB2247
Sunquest Order Code: PLVX

Specimen Required

Container Type:

Optimal:  Two 1.8 mL BD brand or 2.0 Greiner brand sodium citrate tubes

Acceptable: One 1.8 mL BD or one 2.0 mL Greiner sodium citrate tube

Unacceptable: 2.7 mL sodium citrate tubes
Optimal Collection Volume: 

3.6 mL whole blood

Tube must be filled to proper level as indicated by opaque line etched on each blue top tube.
Collection Instructions:
  • Tube must be filled to line.
  • Gently invert 5 to 10 times to mix blood.
  • If collected through a blood collection set (butterfly), a discard tube must first be drawn to eliminate dead space from tubing.
Processing Instructions: 

1. Do not centrifuge sample.

2. Testing must not be performed sooner than 10 minutes after collection and later than 4 hours after collection.

Useful For

Measures the level of platelet P2Y12-receptor blockade to help identify patient response to antiplatelet therapy, including clopidogrel (Plavix), prasugrel (Effient) and ticagrelor (Brilinta).

Method Name

The VerifyNow System is a turbidimetric based optical detection system which measures platelet induced aggregation. 

Stability Information

Specimen Type Temperature Time
Whole Blood Ambient 4 hours

Rejection Due To

Hemolysis Mild OK; Moderate OK; Gross Reject
Lipemia Mild OK; Moderate OK; Gross Reject
Icterus Mild OK; Moderate OK; Gross Reject
Other

Centrifuged sample- Reject

2.7 mL blue top collections- Reject 

Tube not full- Reject

Clotted Sample- Reject

Sample refrigerated or frozen- Reject

 

Specimen Minimum Volume

Collecting minimum volumes can result in a need for sample recollection, and/or a delay in results. Minimum volumes are subjective and cannot account for all aspects of specimen and testing needs. Refer to the Specimen Required section for optimal volumes for laboratory specimens. Contact the Bronson Laboratory if complex collection exceptions occur that require more information.

 

Minimum Volume: Two 1.8 mL blue top citrate tubes
Neonate Volume: One 1.8 mL blue top citrate tubes

Performing Laboratory

Bronson Laboratory, Coagulation- Kalamazoo

Day(s) Performed

24/7

Reference Values

  • Pre-drug reference range: 194-418 PRU
  • Post-drug results:
    • A lower PRU indicates drug efficacy (less platelet aggregation). 
    • A higher PRU value indicates drug resistance (more platelet aggregation).
    • Published data suggests that post drug PRU values <or = 230 are associated with better clinical outcomes.
    • Post drug PRU values >230 are associated with higher rates of death, MI, or stent thrombosis.

LOINC Code Information

24377-4

CPT Code Information

85576

Sample Retention Time

24 Hours

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