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HelpTest Code TIGE or LAB74 IgE, Total, Serum
Specimen Requirements
| Container Type: |
Optimal: Gold Acceptable: Red
|
| Optimal Collection Volume: |
4.5mL; full tube |
| Minimum Volume: |
3 mL |
| Collection Instructions: |
Gently invert the sample 5-6 times after collection. |
| Specimen Transport: |
Refrigerate |
| Processing Instructions: |
1. Allow the specimen to clot for 30 minutes. 2. Centrifuge specimen within 2 hours of collection. 3. After centrifugation, specimen tubes without a gel barrier should have the serum aliquoted to a false bottom container. 4. Keep serum refrigerated until testing can be performed. |
Specimen Stability
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated | 7 days |
| Room Temperature | 24 hours |
Specimen Rejection Criteria
Quantity not sufficient
Useful For
Diagnostic aid in the clinical diagnosis of IgE-mediated allergic disorders in conjunction with other clinical findings.
Methodology
Phadia ImmunoCAP - Fluorescence enzyme immunoassay
Reference Ranges
The normal range for Total Serum IgE represents 1 SD* (Standard Deviation) for that particular age group in the population. Serum IgE levels greater than 1 SD suggest the presence of allergic disease. Serum IgE levels greater than 2 SD* strongly suggest the presence of allergic disease.
*The SD ranges are dependent on the age of the patient. Please reference the table below for age-specific 1 and 2 SD ranges.
| Total IgE - Grouped by Age | |||
|---|---|---|---|
| Age | Mean (kU/L) | +1SD (kU/L) | +2SD (kU/L) |
| 0-6 weeks | 0.6 | 2.3 | 4.0 |
| 7 weeks-3 months | 1.0 | 4.1 | 7.2 |
| 4-6 months | 1.8 | 7.3 | 13.0 |
| 7-9 months | 2.6 | 10.0 | 17.0 |
| 10-23 months | 3.2 | 13.0 | 23.0 |
| 2 years | 5.7 | 23.0 | 40.0 |
| 3 years | 8.0 | 32.0 | 56.0 |
| 4 years | 10.0 | 40.0 | 70.0 |
| 5 years | 12.0 | 48.0 | 84.0 |
| 6 years | 14.0 | 56.0 | 98.0 |
| 7 years | 16.0 | 63.0 | 110.0 |
| 8 years | 18.0 | 71.0 | 124.0 |
| 9 years | 20.0 | 78.0 | 136.0 |
| 10 years | 22.0 | 85.0 | 148.0 |
| Adults | 3.2 | 41.0 | 69.0 |
|
After peaking at 10 years, serum total IgE levels decline to adult values. |
|||
Interpretive
Total IgE
Elevated concentrations of total immunoglobulin E (IgE) may be found in various clinical diseases, including allergic disease, certain primary immunodeficiencies, infections, inflammatory diseases, and malignancies.
Elevated total IgE concentrations may be consistent with a diagnosis of allergic bronchopulmonary aspergillosis, provided other laboratory and clinical criteria are fulfilled.
Source: Mayo Clinical Labs
Day(s) Performed
Monday through Friday
Expected TAT
Same day or 1-3 days
Performing Laboratory
Bronson Laboratory, Chemistry - Kalamazoo
Sample Retention Time
7 days
CPT Code
82785
LOINC Code
19113-0