Home
HelpTest Code PNEFS Neuroimmunology Antibody Follow-up, Serum
Reporting Name
Neuroimmunology Ab Follow-up, SUseful For
Monitoring patients who have previously tested positive for 1 or more antibodies within the past 5 years in a Mayo Neuroimmunology Laboratory serum evaluation
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ARMO | ACh Receptor (Muscle) Modulating Ab | No | No |
| GANG | AChR Ganglionic Neuronal Ab, S | No | No |
| AMPCS | AMPA-R Ab CBA, S | No | No |
| AMPIS | AMPA-R Ab IF Titer Assay, S | No | No |
| AMPHS | Amphiphysin Ab, S | No | No |
| AGN1S | Anti-Glial Nuclear Ab, Type 1 | No | No |
| ANN1S | Anti-Neuronal Nuclear Ab, Type 1 | No | No |
| ANN2S | Anti-Neuronal Nuclear Ab, Type 2 | No | No |
| ANN3S | Anti-Neuronal Nuclear Ab, Type 3 | No | No |
| CS2CS | CASPR2-IgG CBA, S | No | No |
| CRMS | CRMP-5-IgG, S | No | No |
| DPPCS | DPPX Ab CBA, S | No | No |
| DPPTS | DPPX Ab IFA Titer, S | No | No |
| DPPIS | DPPX Ab IFA, S | No | No |
| GABCS | GABA-B-R Ab CBA, S | No | No |
| GABIS | GABA-B-R Ab IF Titer Assay, S | No | No |
| LG1CS | LGI1-IgG CBA, S | No | No |
| GL1CS | mGluR1 Ab CBA, S | No | No |
| GL1TS | mGluR1 Ab IFA Titer, S | No | No |
| GL1IS | mGluR1 Ab IFA, S | No | No |
| VGKC | Neuronal (V-G) K+ Channel Ab, S | No | No |
| NMDCS | NMDA-R Ab CBA, S | No | No |
| NMDIS | NMDA-R Ab IF Titer Assay, S | No | No |
| CCN | N-Type Calcium Channel Ab | No | No |
| CCPQ | P/Q-Type Calcium Channel Ab | No | No |
| PCABP | Purkinje Cell Cytoplasmic Ab Type 1 | No | No |
| PCAB2 | Purkinje Cell Cytoplasmic Ab Type 2 | No | No |
| PCATR | Purkinje Cell Cytoplasmic Ab Type Tr | No | No |
Method Name
ANN1S, ANN2S, ANN3S, AGN1S, PCABP, PCAB2, PCATR, AMPHS, CRMS, AMPIS, GABIS, NMDIS, DPPIS, DPPTS, GL1IS, GL1TS: Indirect Immunofluorescence (IFA)
AMPCS, GABCS, NMDCS, LG1CS, CS2CS, DPPCS, GL1CS: Cell-Binding Assay (CBA)
WBN, ABLOT: Western Blot
CCPQ, CCN, GANG, VGKC, ARMO: Radioimmunoassay (RIA)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumAdvisory Information
This test is only appropriate for follow-up in patients who have previously tested positive in a serum test. If patients have not previously been positive in a serum test, order 1 of the following:
-PAVAL / Paraneoplastic, Autoantibody Evaluation, Serum
-GID1 / Autoimmune Gastrointestinal Dysmotility Evaluation, Serum
-DYS1 / Autoimmune Dysautonomia Evaluation, Serum
-DMS1 / Dementia, Autoimmune Evaluation, Serum
-ENS1 / Encephalopathy, Autoimmune Evaluation, Serum
-EPS1 / Epilepsy, Autoimmune Evaluation, Serum
-MDS1 / Movement Disorder Evaluation, Serum
-MGL1 / Myasthenia Gravis (MG)/Lambert-Eaton Syndrome (LES) Evaluation
-MGA1 / Myasthenia Gravis (MG) Evaluation, Adult
-MGP1 / Myasthenia Gravis (MG) Evaluation, Pediatric
-MGT1 / Myasthenia Gravis (MG) Evaluation, Thymoma
-MGRM / Myasthenia Gravis Evaluation with MuSK Reflex, Serum
Specimen Required
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: 13- x 75-mm plastic screw-top vial.
Specimen Volume: 4 mL
Collection Instructions: Centrifuge within 2 hours. Aliquot and ship in 13- x 75-mm plastic screw-top vial.
Specimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 72 hours |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Reference Values
|
Test ID |
Reporting Name |
Reference Value |
|
GANG |
AChR Ganglionic Neuronal Ab, S |
<0.02 |
|
AMPCS |
AMPA-R Ab CBA, S |
Negative |
|
AMPIS |
AMPA-R Ab IF Titer Assay, S |
<1:120 |
|
AMPHS |
Amphiphysin Ab, S |
<1:240 |
|
ABLOT |
Amphiphysin Western Blot, S |
Negative |
|
AGN1S |
Anti-Glial Nuclear Ab, Type 1 |
<1:240 |
|
ANN1S |
Anti-Neuronal Nuclear Ab, Type 1 |
<1:240 |
|
ANN2S |
Anti-Neuronal Nuclear Ab, Type 2 |
<1:240 |
|
ANN3S |
Anti-Neuronal Nuclear Ab, Type 3 |
<1:240 |
|
CS2CS |
CASPR2-IgG CBA, S |
Negative |
|
CRMS |
CRMP-5-IgG, S |
<1:240 |
|
GABCS |
GABA-B-R Ab CBA, S |
Negative |
|
GABIS |
GABA-B-R Ab IF Titer Assay, S |
<1:120 |
|
LG1CS |
LGI1-IgG CBA, S |
Negative |
|
VGKC |
Neuronal (V-G) K+ Channel Ab, S |
<0.02 |
|
NMDCS |
NMDA-R Ab CBA, S |
Negative |
|
NMDIS |
NMDA-R Ab IF Titer Assay, S |
<1:120 |
|
NMOTS |
NMO/AQP4 FACS Titer, S |
<1:5 |
|
CCN |
N-Type Calcium Channel Ab |
<0.03 |
|
CCPQ |
P/Q-Type Calcium Channel Ab |
<0.02 |
|
WBN |
Paraneoplastic Autoantibody WBlot,S |
Negative |
|
PCABP |
Purkinje Cell Cytoplasmic Ab Type 1 |
<1:240 |
|
PCAB2 |
Purkinje Cell Cytoplasmic Ab Type 2 |
<1:240 |
|
PCATR |
Purkinje Cell Cytoplasmic Ab Type Tr |
<1:240 |
Day(s) and Time(s) Performed
ANN1S, ANN2S, ANN3S, AGN1S, PCABP, PCAB2, PCATR, AMPHS, CRMS, AMPIS, GABIS, NMDIS, DPPIS, DPPTS, GL1IS, GL1TS:
Monday through Friday; 11:30 a.m. and 8 p.m.
Saturday and Sunday 8 a.m.
AMPCS, GABCS, NMDCS. LG1CS, CS2CS, DPPCS, GL1CS:
Monday through Friday; 6 a.m.
WBN, ABLOT:
Monday, Wednesday, Friday; 8 a.m.
CCPQ, CCN, GANG, VGKC:
Monday through Friday; 11 a.m. and 6 p.m.
Saturday, Sunday; 6 a.m.
ARMO:
Monday through Thursday, Saturday; 12 p.m.
Sunday; 8 a.m.
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
83519-59-ACh receptor (muscle) modulating antibodies (if appropriate)
83519-59-AChR ganglionic neuronal antibody (if appropriate)
83519-59-N-type calcium channel antibody (if appropriate)
83519-59-P/Q-type calcium channel antibody (if appropriate)
83519-VGKC (if appropriate)
84182-CRMP-5-IgG Western blot (if appropriate)
84182-Paraneoplastic autoantibody Western blot confirmation (if appropriate)
86255-Amphiphysin (if appropriate)
86255-ANNA-1 (if appropriate)
86255-ANNA-2 (if appropriate)
86255-ANNA-3 (if appropriate)
86255-CRMP-5-IgG (if appropriate)
86255-PCA-1 (if appropriate)
86255-PCA-2 (if appropriate)
86255-PCA-Tr (if appropriate)
86255-DPPCS (if appropriate)
86255-DPPIS (if appropriate)
86255-GL1CS (if appropriate)
86255-GL1IS (if appropriate)
86255-NMDCS (if appropriate)
86255-AMPCS (if appropriate)
86255-GABCS (if appropriate)
86256-NMDIS (if appropriate)
86256-AMPIS (if appropriate)
86256-GABIS (if appropriate)
86256-DPPTS (if appropriate)
86256-GL1TS (if appropriate)
86255-LG1CS (if appropriate)
86255-CS2CS (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PNEFS | Neuroimmunology Ab Follow-up, S | 80615-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 84300 | Neuroimmunology Ab Follow-up, S | 80615-8 |
Forms
If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.