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Test Code MMP-7 MMP-7 Matrix Metalloproteinase 7

Additional Codes

MIMAY-;ZW140 MMP-7 Matrix Metalloproteinase 7

Ref Code: MML1556

Specimen Requirements

Collect: 1 mL blood in Gold or Red top.

Laboratory Instructions: Specimen should be spun, separated, and frozen within 2 hrs of collection.

Minimum Volume: 0.5 mL Serum 

Methodology

Elisa

Expected TAT

2-8 Day TAT

Performing Laboratory

Metabolic Laboratory Children’s Medical Center 1935 Medical District Drive Dallas, TX 75235 

CPT Code

83520

Shipping instructions (BMH Sendouts only)

Test information can be found in the Referral catalog on the Mayo website. test is sent out as a MIMAY with the completed Requisition form. Send sample frozen. 

Reference Range

Reference Interval

3.6-10.5 ng/mL

 

Interpretation

Interpretive Data

< 17 ng/mL - 95% sensitivity, 97% negative predictive value.  Below 17 ng/mL, the chance is 95% that biliary atresia will not be present.
 
17-68 ng/mL - indeterminate.  Differential in this range would include biliary atresia, but also things like indeterminate cholestasis, choledocal cyst, alpha-1-antitrypsin deficiency.
 
>68 ng/mL - 95% specificity, 69% positive predictive value.  Above 68 ng/mL, the likelihood of biliary atresia is 95% 

Caution should be exercised in the interpretation of any assay for MMP-7, and the results should be considered in conjunction with the patient’s clinical condition. High MMP-7 have been detected in premature babies and young infants with cardiovascular and/ or multi-system disease. The final diagnosis of biliary atresia requires intraoperative cholangiography and the histological presence of obstruction of the extrahepatic bile duct. The normal values of MMP-7 in premature babies have not yet been established. Clinical correlation is particularly important in premature babies.

The performance characteristics of this assay were validated by the Metabolics Laboratory Children's Health. Reagents used in this assay are used in many lab tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration approval. Children's Health is authorized under the Clinical Laboratory Improvement Amendments of 1988(CLIA-88) to perform high complexity testing. This test should not be regarded as investigational or for research use.
 

Performing days

Monday, Wednesday, and Friday*
*Testing not performed on holidays or weekends

Sample Stability

Frozen 6 Months. 

Rejection Criteria

Thawed samples, plasma samples