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HelpTest Code IGG or LAB71 Immunoglobulin G (IgG), Serum or Plasma
Specimen Requirements
| Container Type: |
Optimal: Gold or Mint* *For STAT requests |
|
Acceptable: Red or Green |
|
| Optimal Collection Volume: |
4.5mL; full tube |
| Minimum Volume: |
1 mL whole blood |
| Collection Instructions: |
Gently invert the sample 5-6 times after collection. |
| Specimen Transport: |
Refrigerate |
| Processing Instructions: |
1. If serum, allow the specimen to clot for 30 minutes. 2. Centrifuge specimen within 2 hours of collection. 3. After centrifugation, specimen tubes without a gel barrier should have the serum or plasma aliquoted to a false bottom container. 4. Keep serum or plasma refrigerated until testing can be performed. |
Specimen Stability
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum* | Refrigerated | 8 months |
| Room Temperature | 4 months | |
| Frozen | 8 months |
*Note: Heparinized plasma in gel separator tubes is less stable than serum and is only suitable for add-on testing up to 2 days following sample collection.
Specimen Rejection Criteria
| Hemolysis | Mild OK; Moderate OK; Gross Reject |
| Lipemia | Mild OK; Moderate OK; Gross Reject |
| Icterus | Mild OK; Moderate OK; Gross Reject |
| Other | Quantity not sufficient |
Useful For
Detecting and monitoring IgG-related disorders
Methodology
Roche Cobas - Immunoturbidimetric assay
Reference Ranges
| Age | Reference Range (mg/dL) |
|---|---|
| Adults | 613-1400 |
| Newborns | 611-1541 |
| 1-6 months | 165-781 |
| 7-12 months | 208-1026 |
| 1-3 years | 331-1090 |
| 4-5 years | 444-1187 |
| 6-8 years | 608-1229 |
| 9-10 years | 583-1509 |
Interpretive
Increased serum immunoglobulin concentrations occur due to polyclonal or oligoclonal immunoglobulin proliferation in hepatic disease (hepatitis, liver cirrhosis), connective tissue diseases, acute and chronic infections, as well as in the cord blood of neonates with intrauterine and perinatal infections.
Elevation of IgG may occur in monoclonal gammopathies such as multiple myeloma, primary systemic amyloidosis, monoclonal gammopathy of undetermined significance, and related disorders.
Decreased levels are found in patients with primary or secondary immune deficiencies.
Source: Mayo Medical Labs
Day(s) Performed
24/7
Expected TAT
Same day
Performing Laboratory
Bronson Laboratory, Chemistry - Kalamazoo and Battle Creek
Sample Retention Time
7 days
CPT Code
82784
LOINC Code
2465-3