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Test Code CRPHS or LAB150 CRP, High Sensitivity, Serum or Plasma

Important Note

High Sensitivity CRP (CRPHS) measures CRP at very low levels. CRPHS is more precise than standard CRP when measuring baseline (i.e., normal) concentrations and enables a measure of chronic inflammation.

Atherosclerosis is an inflammatory disease, and multiple guidelines have endorsed CRPHS as a biomarker of atherosclerotic cardiovascular disease risk. (European 2011, Goff 2013, Jacobson 2014).   CRPHS should be used to assess the risk of cardiovascular disease or events. To monitor or asses other inflammatory disorders, please order CRP (LAB149)

Specimen Requirements

Container Type:

Optimal: Gold or Mint*

*For STAT requests

Acceptable: Red or Green
Optimal Collection Volume: 

4.5mL; full tube
Minimum Volume:

1 mL whole blood
Collection Instructions:

Gently invert the sample 5-6 times after collection.
Specimen Transport:

Refrigerate
Processing Instructions: 

1. If serum, allow the specimen to clot for 30 minutes.

2. Centrifuge specimen within 2 hours of collection.

3. After centrifugation, specimen tubes without a gel barrier should have the serum or plasma aliquoted to a false bottom container.

4. Keep the serum or plasma refrigerated until testing can be performed.

Specimen Stability

Specimen Type Temperature Time
Serum* Refrigerated 8 days
Room Temperature 3 days
Frozen 3 years

*Note: Heparinized plasma in gel separator tubes is less stable than serum and is only suitable for add-on testing up to 2 days following sample collection.

Specimen Rejection Criteria

Hemolysis Mild OK; Moderate OK; Gross Reject
Lipemia Mild OK; Moderate OK; Gross Reject
Icterus Mild OK; Moderate OK; Gross Reject
Other Quantity not sufficient

Useful For

This assay is useful in assessing the risk of cardiovascular disease.

Methodology

Roche Cobas - Immunoturbidimetric

Reference Ranges

Reference Range and Reporting Units

Relative Cardiac Risk Category

< 1.0 mg/L

Low

1.0-3.0 mg/L

Average

> 3.0-10.0 mg/L

High

> 10.0 mg/L

Investigate for non-cardiac source of infection or inflammation

Day(s) Performed

24/7

Expected TAT

Same day

Performing Laboratory

Bronson Laboratory, Chemistry - Kalamazoo

Sample Retention Time

7 days

CPT Code

86141

LOINC Code

30522-7