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HelpTest Code SFLC or LAB735 Serum Free Light Chains, Serum
Profile Information
|
Test ID |
Reporting Name |
Available Separately? |
Always Performed? |
|---|---|---|---|
|
KAPPA |
Kappa Free Light Chains |
N |
Y |
|
LAMBDA |
Lambda Free Light Chains |
N |
Y |
Specimen Requirements
| Container Type: |
Optimal: Gold Acceptable: Red |
| Optimal Collection Volume: |
4.5mL; full tube |
| Minimum Volume: |
2 mL whole blood |
| Collection Instructions: |
Gently invert the sample 5-6 times after collection. |
| Specimen Transport: |
Refrigerate |
| Processing Instructions: |
1. Allow the specimen to clot for 30 minutes. 2. Centrifuge specimen within 2 hours of collection. 3. After centrifugation, specimen tubes without a gel barrier should have the serum aliquoted to a false bottom container. 4. Keep the serum refrigerated until testing can be performed. |
Specimen Stability
|
Specimen Type |
Temperature |
Time |
|---|---|---|
|
Serum |
Refrigerated |
21 days |
Specimen Rejection Criteria
Quantity not sufficient
Useful For
Measurement of free light chains aids in the diagnosis and monitoring of multiple myeloma, lymphocytic neoplasms, Waldenstrom’s macroglobulinemia, AL amyloidosis, light chain deposition disease, and connective tissue diseases such as systemic lupus erythematosus in conjunction with other laboratory and clinical findings.
Methodology
Roche Cobas - The Binding Site (Closed Development Channel) Immunoturbidimetric
Reference Ranges
|
Test ID |
Mean Concentration (mg/L) |
Median Concentration (mg/L) |
95 Percentile (mg/L) |
|---|---|---|---|
|
Free Kappa |
8.36 |
7.30 |
3.30-19.40 |
|
Free Lambda |
13.43 |
12.40 |
5.71-26.30 |
|
Test ID |
Mean concentration |
Median concentration |
95 Percentile |
|---|---|---|---|
|
Free Kappa/Free Lambda Ratio |
0.63 |
0.60 |
0.26-1.65* |
*up to 3.1 for patients with renal insufficiency or polyclonal hypergammopathy
Day(s) Performed
24/7
Expected TAT
Same day
Performing Laboratory
Bronson Laboratory, Chemistry - Kalamazoo
Sample Retention Time
7 days
CPT Code
83521 x 2
LOINC Code
48378-4