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Test Code VASCL or LAB2291 Vasculitis Panel, Serum

Profile Information

Test ID   Reporting Name Available Separately? Always Performed?
MYELOP Myeloperoxidase IgG Y Y
PRTNASE Proteinase 3 IgG Y Y
GBM* GBM IgG Y Y

*Glomerular Basement Membrane

Specimen Requirements

Container Type:

Optimal: Gold

Acceptable: Red
Optimal Collection Volume: 

4.5 mL; full tube
Minimum Volume: 2 mL
Collection Instructions:

Gently invert the sample 5-6 times after collection.
Specimen Transport:

Refrigerate
Processing Instructions: 

1. Allow sample to clot for 30 minutes.

2. Centrifuge specimen within 2 hours of collection.

3. Separate serum into a false bottom container.

4. Keep serum refrigerated until testing can be performed.

Specimen Stability

Specimen Type Temperature Time
Serum Refrigerated 7 days
Room Temperature 8 hours

Specimen Rejection Criteria

Hemolysis Mild OK; Moderate OK; Gross Reject
Lipemia Mild OK; Moderate OK; Gross Reject
Icterus Mild OK; Moderate OK; Gross Reject
Other Quantity not sufficient

Useful For

In conjunction with clinical findings, the Vasculitis Panel aids in the diagnosis of anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: Microscopic Polyangiitis (MPA), Necrotizing Glomerulonephritis, Churg-Strauss Syndrome, Wegener’s Granulomatosis, and the autoimmune renal disorder, Goodpasture’s syndrome.

Methodology

Bio-Rad BioPlex 2200: Multiplex flow immunoassay

Reference Ranges

 Test ID   Reference Range and Reporting Units
MYELOP Negative: < 1.0 AI
Positive: > 1.0 AI
PRTNASE Negative: < 1.0 AI
Positive: > 1.0 AI
GBM Negative: < 1.0 AI
Positive: > 1.0 AI

 

Note: If either MYELOP or PRTNASE result is positive, the test NCABX (LAB458) is reflex ordered for confirmatory Antineutrophil cytoplasmic antibodies, which is performed at Mayo Reference Lab.

 

Interpretive

VASC - Clinical & Interpretive: Antineutrophil Cytoplasmic Antibodies Vasculitis Panel, Serum (mayocliniclabs.com)

Day(s) Performed

Monday through Friday

Expected TAT

Same day or 1-2 days

Performing Laboratory

Bronson Laboratory, Chemistry - Kalamazoo

Sample Retention Time

7 days

CPT Code

83516 x 3

LOINC Code

  • MYELOP: 46266-3
  • PRTNASE: 74106-6
  • GBM: 68386-2