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Test Code PLA2I Phospholipase A2 Receptor, Immunofluorescence, Serum


Ordering Guidance


This test can be used in a complementary fashion with a quantitative enzyme-linked immunosorbent assay to confirm a positive result, especially if it is a low-level titer. Since the immunofluorescence is more sensitive, it can also be used to detect or follow patients with low level antibodies not detected by ELISA.  



Specimen Required


Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL 

Collection Instructions: Centrifuge and aliquot serum into a plastic vial within 2 hours of collection.


Useful For

Distinguishing primary from secondary membranous nephropathy in patients with low levels of anti-phospholipase A2 receptor (PLA2R) antibodies

 

Screening for anti-PLA2R antibodies

 

Monitoring patients with membranous nephropathy at very low antibody titers

Reporting Name

PLA2R, Immunofluorescence, S

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  8 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia OK

Reference Values

Negative

Day(s) Performed

Monday, Wednesday, Friday

Report Available

3 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86255

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PLA2I PLA2R, Immunofluorescence, S 82991-1

 

Result ID Test Result Name Result LOINC Value
PLA2I PLA2R, Immunofluorescence, S 82991-1

Forms

If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.