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Test Code MIMAY-ZW242 SEQ2 Maternal Screening, Sequential, Specimen #2, Alpha Fetoprotein, hCG, Estriol, and Inhibin A

Important Note

Patient Preparation:

Specimen must be drawn between 14 weeks, 0 days and 24 weeks, 6 days gestation. The recommended time for maternal serum screening is 16 to 18 weeks gestation.

Requires that a previous first trimester specimen, Maternal Screening, Sequential, Specimen #1, hCG, PAPP-A, NT (ARUP test code 3000146), has been performed.

Additional Codes

MIMAY-ZW242

REF CODE: 3000148

AKA: Sequential Screen Part 2, Second Trimester screen

Profile Information

Second-trimester screening test for trisomy 21 (Down syndrome), trisomy 18, and open neural tube defects. Requires a previously submitted first-trimester specimen, Maternal Screening, Sequential, Specimen #1, hCG, PAPP-A, NT (3000146). Also requires nuchal translucency measurement performed by an ultrasonographer certified by the Fetal Medicine Foundation (FMF). Risks provided in both first and second trimesters.

Specimen Requirements

Collect: Serum separator tube (SST) or plain red.

Specimen Preparation: Separate from cells ASAP or within 2 hours of collection. Transfer 3 mL serum to an ARUP standard transport tube. 

Specimen Volume: 3mL (Min 1mL)

Storage/Transport Temperature: Refrigerated

Specimen Stability

After separation from cells: Ambient: 72 hours; Refrigerated: 2 weeks; Frozen: 1 year (Avoid repeated freeze/thaw cycles.)

Specimen Rejection Criteria

Plasma. Hemolyzed specimens.

Methodology

Quantitative Chemiluminescent Immunoassay

Reference Ranges

By Report

Day(s) Performed

Sun-Sat

Expected TAT

2-4 Days

Performing Laboratory

ARUP Laboratories

500 chipeta Way

Salt Lake City, UT 84108

CPT Code

81511