Test Code MFK506 Tacrolimus, Blood
Additional Codes
Mayo Code |
TAKRO |
EPIC Code |
LAB876 |
Sunquest Code |
MFK506 |
Reporting Name
Tacrolimus, BUseful For
Monitoring whole blood tacrolimus concentration during therapy, particularly in individuals coadministered CYP3A4 substrates, inhibitors, or inducers
Adjusting dose to optimize immunosuppression while minimizing toxicity
Evaluating patient compliance
Method Name
High-Performance Liquid Chromatography/Tandem Mass Spectrometry (HPLC-MS/MS)
Performing Laboratory

Specimen Type
Whole Blood EDTASpecimen Required
Container/Tube: Lavender top (EDTA)
Specimen Volume: 3 mL
Collection Instructions:
1. Draw blood immediately before a schedule dose.
2. Do not centrifuge.
3. Send specimen in original tube.
Additional Information: Therapeutic range applies to trough specimens drawn immediately prior to a.m. dose.
Specimen Minimum Volume
1 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Whole Blood EDTA | Refrigerated (preferred) | 14 days | |
Ambient | 14 days | ||
Frozen | 14 days |
Reject Due To
Gross hemolysis | OK |
Gross lipemia | OK |
Gross icterus | OK |
Reference Values
5.0-15.0 ng/mL (Trough)
Target steady-state trough concentrations vary depending on the type of transplant, concomitant immunosuppression, clinical/institutional protocols, and time post-transplant. Results should be interpreted in conjunction with this clinical information and any physical signs/symptoms of rejection/toxicity.
Day(s) and Time(s) Performed
Monday through Friday; Continuous until 3 p.m.
Saturday, Sunday; Continuous until 1 p.m.
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
80197
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
TAKRO | Tacrolimus, B | 77348-1 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
35145 | Tacrolimus, B | 77348-1 |
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-General Request (T239)
-Renal Diagnostics Test Request (T830)
-Therapeutics Test Request (T831)