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Test Code MFK506 Tacrolimus, Blood

Additional Codes

 

Mayo Code
TAKRO
EPIC Code
LAB876
Sunquest Code
MFK506

 

Reporting Name

Tacrolimus, B

Useful For

Monitoring whole blood tacrolimus concentration during therapy, particularly in individuals coadministered CYP3A4 substrates, inhibitors, or inducers

 

Adjusting dose to optimize immunosuppression while minimizing toxicity

 

Evaluating patient compliance

Method Name

High-Performance Liquid Chromatography/Tandem Mass Spectrometry (HPLC-MS/MS)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Whole Blood EDTA


Specimen Required


Container/Tube: Lavender top (EDTA)

Specimen Volume: 3 mL

Collection Instructions: 

1. Draw blood immediately before a schedule dose.

2. Do not centrifuge.

3. Send specimen in original tube.

Additional Information: Therapeutic range applies to trough specimens drawn immediately prior to a.m. dose.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood EDTA Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

5.0-15.0 ng/mL (Trough)

 

Target steady-state trough concentrations vary depending on the type of transplant, concomitant immunosuppression, clinical/institutional protocols, and time post-transplant. Results should be interpreted in conjunction with this clinical information and any physical signs/symptoms of rejection/toxicity.

Day(s) and Time(s) Performed

Monday through Friday; Continuous until 3 p.m.

Saturday, Sunday; Continuous until 1 p.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80197

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TAKRO Tacrolimus, B 77348-1

 

Result ID Test Result Name Result LOINC Value
35145 Tacrolimus, B 77348-1

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-General Request (T239)

-Renal Diagnostics Test Request (T830)

-Therapeutics Test Request (T831)