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Test Code HBC or LAB2584 Hepatitis B Core Antibody, Total

Important Note

NOTE: Test not live - Until this comment is removed, Order the Mayo sendout test LAB1242

  • If Total is requested, order this test HBC (LAB2584).
  • If IgM is requested, order HBMC (LAB549).
  • If IgG and IgM are requested, order HBC (LAB2584) and HBMC(LAB549) Note: There is no IgG only test; there fore a positive HBC Total and a negative HBC IgM suggests IgG. 

Patient Preparation: For 12 hours before HBC do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins. Biotin can interfere with many immunoassay tests.

 

Specimen Requirements

Container Type:

Optimal: Gold 

Acceptable: Red,  or Mint Green (Lithium Heparin)

 
Optimal Collection Volume: 

4.5mL; full tube
Minimum Volume:

1 mL whole blood
Collection Instructions:

Gently invert the sample 5-6 times after collection.
Specimen Transport:

Refrigerate
Processing Instructions: 

1. Allow the specimen to clot for 30 minutes.

2. Centrifuge specimen within 2 hours of collection.

3. After centrifugation, specimen tubes without a gel barrier should have the serum aliquoted to a false bottom container.

4. Keep the serum refrigerated until testing can be performed.

Specimen Stability

Specimen Type Temperature Time
Serum Refrigerated 14 days
Room Temperature 7 days
Frozen 3 months

Specimen Rejection Criteria

Hemolysis Mild OK; Moderate OK; Gross Reject
Lipemia Mild OK; Moderate OK; Gross Reject
Icterus Mild OK; Moderate OK; Gross Reject
Other Quantity not sufficient

Useful For

Diagnosis of recent or past hepatitis B

Determination of occult hepatitis B in otherwise healthy hepatitis B virus carriers with negative test results for hepatitis B surface (HBs) antigen, anti-HBs, anti-HB core IgM, hepatitis Be (HBe) antigen, and anti-HBe

This assay is not useful for differentiating among acute, chronic, and past or resolved hepatitis B

Methodology

Roche Cobas - Electrochemiluminescence immunoassay

Reference Ranges

Negative

Interpretive

HBC - Overview: Hepatitis B Virus Core Total Antibodies, Serum

Day(s) Performed

24/7

Expected TAT

Same day

Performing Laboratory

Bronson Laboratory, Chemistry - Kalamazoo 

Sample Retention Time

7 days

CPT Code

86704

LOINC Code

13952-7