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Test Code FFCAH Congenital Adrenal Hyperplasia (CAH) Pediatric Profile 6, Comprehensive Screen

Important Note

This test can inclued a baseline and 60 minute draw.

Spin seperate and freeze within 1 hour.


Specimen Required


Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 3.5 mL Serum

Collection Instructions:

1. Within 45 minutes of collection, centrifuge and aliquot serum into a plastic vial.

2. Send frozen.

Additional Information: To avoid delays in turnaround time when requesting multiple tests, submit separate frozen specimens for each test requested.


Reporting Name

CAH Profile 6

Specimen Type

Serum Red

Specimen Minimum Volume

Serum: 2 mL Note: This volume does not allow for repeat testing.

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Frozen 90 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icteric Reject

Reference Values

Androstenedione:

Premature (26-28 weeks) Day 4: 63-935 ng/dL

Premature (31-35 weeks) Day 4: 50-449 ng/dL

Full Term (1-7 days): <10-279 ng/dL

Levels decrease rapidly to <52 ng/dL after one week.

1 month-11 months: <10-37 ng/dL

Androstenedione gradually decreases during the first six months to prepubertal levels.

Prepubertal Children: <10-17 ng/dL

Adults

Males: 44-186 ng/dL

Females: 2 -230 ng/dL

Females Postmenopausal: <10-93 ng/dL

 

Cortisol:

Premature (26-28 weeks) Day 4: 1.0-11 ug/dL

Premature (31-35 weeks) Day 4: 2.5-9.1 ug/dL

Full Term Day 3: 1.7-14 ug/dL

Full Term Day 7: 2.0-11 ug/dL

31 days-11 months: 2.8-23 ug/dL

12 months-15 years (8 a.m.): 3.0-21 ug/dL

Adults

8 a.m.: 8.0-19 ug/dL

4 p.m.: 4.0-11 ug/dL

 

Deoxycorticosterone (DOC):

Premature (26-28 weeks) Day 4: 20-105 ng/dL

Premature (34-36 weeks) Day 4: 28-78 ng/dLNewborn: Levels are markedly elevated at birth and decrease rapidly during the first week to the range of 7-49 ng/dL as found in older infants.

1 month-11 months: 7-49 ng/dL

Prepubertal Children: 2-34 ng/dL

Pubertal Children and Adults 8 a.m.: 2-19 ng/dL

 

Dehydroepiandrosterone (DHEA):

Premature (26-31 weeks): 82-1484 ng/dL

Premature (32-35 weeks): 56-1853 ng/dL

Full Term (2-7 days): 41-1292 ng/dL

8 days-5 months: <948 ng/dL

6 months-12 months: <136 ng/dL

1 year-5 years: <68 ng/dL

6-7 years: <111 ng/dL

8-10 years: <186 ng/dL

11-12 years: <202 ng/dL

13-14 years: <319 ng/dL

15-16 years: 39-481 ng/dL

17-19 years: 40-491 ng/dL

20-50 years: 31-701 ng/dL

>50 years: 21-402 ng/dL

 

11-Desoxycortisol:

Premature (26-28 weeks) Day 4: 110-1376 ng/dL

Premature (31-35 weeks) Day 4: 48-579 ng/dL

Full term Newborn Day 3: 13-147 ng/dL

1 month-11 months: <10-156 ng/dL

Prepubertal 8 a.m.: 20-155 ng/dL

Pubertal Children and Adults 8 a.m.: 12-158 ng/dL

 

17-OH Pregnenolone:

Premature (26-28 weeks) Day 4: 375-3559 ng/dL

Premature (31-35 weeks) Day 4: 64-2380 ng/dL

3 days: 10-829 ng/dL

1 month-5 months: 36-763 ng/dL

6-11 months: 42-540 ng/dL

12-23 months: 14-207 ng/dL

24 months-5 years: 10-103 ng/dL

6-9 years: 10-186 ng/dL

Pubertal: 44-235 ng/dL

Adults: 53-357 ng/dL

 

Progesterone:

Males

1 year-16 years: <10-15 ng/dL

Adults: <10-11 ng/dL

Females

1 year-10 years: <10-26 ng/dL

11 years: <10-255 ng/dL

12 years: <10-856 ng/dL

13 years: <10-693 ng/dL

14 years: <10-1204 ng/dL

15 years: <10-1076 ng/dL

16 years: <10-1294 ng/dL

Adult

Cycle days

1-6: <10-17 ng/dL

7-12: <10-135 ng/dL

13-15: <10-1563 ng/dL

16-28: <10-2555 ng/dL

Post Menopausal: <10 ng/dL

Note: Luteal progesterone peaked from 350 to 3750 ng/dL on days ranging from 17 to 23.

 

17-Alpha-Hydroxyprogesterone (17-OHP):

Premature (26-28 weeks) Day 4: 124-841 ng/dL

Premature (31-35 weeks) Day 4: 26-568 ng/dL

Full-Term Day 3: <78 ng/dL

 

Males:

Levels increase after the first week to peak values ranging from 40-200 ng/dL between 30 and 60 days. Values then decline to a prepubertal value of <91 ng/dL before one year.

Prepubertal: <91 ng/dL

Adult: 27-199 ng/dL

 

Females:

1 month-11 months: 13-106 ng/dL

Prepubertal: <91 ng/dL

Adult:

Follicular: 15-70 ng/dL

Luteal: 35-290 ng/dL

 

Testosterone, Total

Males:

Premature (26-28w) Day 4: 59-125 ng/dL

Premature (31-35w) Day 4: 37-198 ng/dL

Newborns: 75-400 ng/dL

1 month-7 months: Levels decrease rapidly the first week to 20-50 ng/dL, then increase to 60-400 ng/dL between 20 and 60 days. Levels then decline to prepubertal range levels of <2.5-10 ng/dL by seven months.

 

Females:

Premature (26-28w) Day 4: 5-16 ng/dL

Premature (31-35w) Day 4: 5-22 ng/dL

Newborns: 20-64 ng/dL

1 month-7 months: Levels decrease during the first month to less than 10 ng/mL and remain there until puberty.

 

Prepubertal Males and Females: <2.5-10 ng/dL

Adult

Males >18 years: 264-916 ng/dL

Females:

Premenopausal: 10-55 ng/dL

Postmenopausal: 7-40 ng/dL

 

Males

Tanner Stage 1 <9.8 years: <2.5-10 ng/mL

Tanner Stage 2 9.8 years-14.5 years: 18-150 ng/mL

Tanner Stage 3 10.7 years-15.4 years: 100-320 ng/mL

Tanner Stage 4 11.8 years-16.2 years: 200-620 ng/mL

Tanner Stage 5 12.8 years-17.3 years: 350-970 ng/mL

Females

Tanner Stage 1 <9.2 years: <2.5-10 ng/mL

Tanner Stage 2 9.2-13.7 years: 7-28 ng/mL

Tanner Stage 3 10.0-14.4 years: 15-35 ng/mL

Tanner Stage 4 10.7-15.6 years: 13-32 ng/mL

Tanner Stage 5 11.8-18.6 years: 20-38 ng/mL

Day(s) Performed

Monday, Wednesday

Report Available

10 to 19 days

Performing Laboratory

Esoterix Endocrinology

CPT Code Information

82633 - DOC

82634 - 11-Desoxycortisol

82157 - Androstenedione

82533 - Cortisol

82626 - DHEA

84143 - 17-OH-Pregnenolone

84144 - Progesterone

83498 - 17-OH-Progesterone

84403 - Testosterone

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FFCAH CAH Profile 6 Not Provided

 

Result ID Test Result Name Result LOINC Value
Z5043 Cortisol 2143-6
Z5044 Deoxycorticosterone (DOC) 1656-8
Z5045 11-Desoxycortisol 1657-6
Z5046 Dehydroepiandrosterone (DHEA) 2193-1
Z5047 17-OH Pregnenolone 6765-2
Z5048 Progesterone 2839-9
Z5049 17-Alpha-Hydroxyprogesterone 17-OHP 1668-3
Z5050 Androstenedione 1854-9
Z5051 Testosterone, Total 2986-8

Test Classification

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.