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Test Code CRGSP Cryoglobulin and Cryofibrinogen Panel, Serum and Plasma

Important Note

Due to strict processing requirements, this test may only be collected at the following Bronson locations:

Bronson Methodist Hospital-
Outpatient Testing 601 John St.South Campus, First Floor Kalamazoo, MI 49007

Bronson Battle Creek Lab-
300 North Ave. Battle Creek, MI 49037

Bronson Lakeview Hospital-
Outpatient Testing 408 Hazen St.Paw Paw, MI 49079

Bronson South Haven Hospital-
955 South Bailey Ave South Haven, MI 49090

**Samples must be kept at 37 degrees Celsius prior to centrifugation. Both Red top and EDTA tubes must incubate at 37 degrees Celsius for 30 - 60 minutes prior to spinning and separating the specimens.

This test requires 2 RED TOPS and 1 LAV

Ensure that aliquots are appropriately labeled as Serum or Plasma.

Additional Codes

Mayo Code

CRGSP

EPIC Code

LAB3213

Beaker Code

CRGSP

Reporting Name

Cryo Panel, S and P

Useful For

Evaluating patients with vasculitis, glomerulonephritis, and lymphoproliferative diseases

 

Evaluating patients with macroglobulinemia or myeloma in whom symptoms occur with cold exposure

 

This test is not useful for general screening of a population without a clinical suspicion of cryoglobulinemia.

Profile Information

Test ID Reporting Name Available Separately Always Performed
CRY_S Cryoglobulin, S Yes Yes
CRY_P Cryofibrinogen, P No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IMFXC Immunofixation Cryoglobulin No No

Testing Algorithm

If cryoglobulin has a positive result after 1 or 7 days, then immunofixation will be performed at an additional charge. Positive cryoglobulins of 0.1 mL or above of precipitate will be typed once.

Performing Laboratory

Mayo Clinic Laboratories in Rochester
Bronson Laboratory Services Note:

Due to strict processing requirements, this test may only be collected at the following Bronson locations:

Bronson Methodist Hospital-
Outpatient Testing 601 John St.South Campus, First Floor Kalamazoo, MI 49007

Bronson Battle Creek Lab-
175 College St.Battle Creek, MI 49037

Bronson Lakeview Hospital-
Outpatient Testing 408 Hazen St.Paw Paw, MI 49079

Bronson South Haven Hospital-
955 South Bailey Ave South Haven, MI 49090

Specimen Type

Plasma EDTA
Serum Red
Bronson Laboratory Services Note:

2 Red 1 lavender


Specimen Required


Both plasma and serum are required.

 

Cryofibrinogen

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Tube must remain at 37° C.

2. Centrifuge at 37° C. (Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable.) It is very important that the specimen remain at 37° C until after separation of plasma from red blood cells.

3. Place plasma into an appropriately labeled plastic vial.

 

Cryoglobulin

Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 5 mL

Collection Instructions:

1. Tube must remain at 37° C.

2. Allow blood to clot at 37° C.

3. Centrifuge at 37° C. (Do not use a refrigerated centrifuge. If absolutely necessary, ambient temperature is acceptable.) It is very important that the specimen remain at 37° C until after separation of serum from red blood cells.

4. Place serum into an appropriately labeled plastic vial.

Additional Information: Analysis cannot be performed with less than 3 mL of serum. Smaller volumes are insufficient to detect clinically important trace (mixed) cryoglobulins. Less than 3 mL will require collection and submission a new specimen.


Bronson Laboratory Services Note:

Samples must be kept at 37 degrees Celsius prior to centrifugation. Both Red top and EDTA tubes must incubate at 37 degrees Celsius for 30 - 60 minutes prior to spinning and separating the specimens.

This test requires BOTH Serum and Plasma.

Ensure that aliquots are appropriately labeled as Serum or Plasma.

Specimen Minimum Volume

Plasma: 0.5 mL
Serum: 3 mL

Bronson Laboratory Services Note:

This test requires BOTH Serum and Plasma.

Ensure that aliquots are appropriately labeled as Serum or Plasma.

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma EDTA Refrigerated (preferred)
  Frozen 
Serum Red Refrigerated (preferred)
  Frozen 

Reference Values

CRYOGLOBULIN

Negative (positives reported as percent or trace amount)

If positive after 1 or 7 days, immunotyping of the cryoprecipitate is performed at an additional charge.

 

CRYOFIBRINOGEN

Negative

Quantitation and immunotyping will not be performed on positive cryofibrinogen.

Day(s) Performed

Monday through Friday

CPT Code Information

82585

82595

86334-Immunofixation (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CRGSP Cryo Panel, S and P 74352-6

 

Result ID Test Result Name Result LOINC Value
2685 Cryofibrinogen, P 11043-7
2684 Cryoglobulin, S 12201-0

Report Available

2 to 10 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Forms

If not ordering electronically, complete, print, and send a Benign Hematology Test Request Form (T755) with the specimen.

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.