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Test Code CLZP Clozapine, Serum

Important Note

Includes Clozapine and Norclozapine. Norclozapine is no longer orderable by itself.

Additional Codes

Mayo Code
CLZ
EPIC Code
LAB2154
Sunquest Code
CLZP

 

Useful For

Monitoring patient compliance of clozapine treatment

 

An aid to achieving desired serum levels

Reporting Name

Clozapine, S

Specimen Type

Serum Red


Ordering Guidance


 



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:  

1. Collect specimen immediately before next scheduled dose.

2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.

Additional Information: Therapeutic range (trough level) applies to specimens collected immediately prior to next dose.


Bronson Laboratory Services Note:

Processing: Centrifuge as soon as possible and remove from cells.

Specimen Minimum Volume

0.6 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  7 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

Clozapine

Therapeutic range: 350-600 ng/mL

 

Norclozapine

Therapeutic range: Not well established

 

Clozapine + Norclozapine

Therapeutic range: Not well established

Day(s) Performed

Monday through Friday

Report Available

3 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80159

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CLZ Clozapine, S 65632-2

 

Result ID Test Result Name Result LOINC Value
33840 Clozapine 6896-5
33841 Norclozapine 10992-6
33842 Clozapine+Norclozapine Total 12375-2

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.