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Test Code CELIAS or LAB2149 Celiac Disease Screen, Serum

Profile Information

Test ID   Reporting Name Available Separately? Always Performed?
TTGA Transglutaminase IgA Y Y
GLDA Gliadin Deamidated IgA Y Y

 

  • If the patient has a low total IgA, a reflex order for Tissue Transglutaminase IgG and Deamidated Gliadin IgG is performed. 
  • For additional information, please click on the Celiac Disease Screen Cascade link in the Resources section of this page.

Specimen Requirements

Container Type:

Optimal: Gold

Acceptable: Red
Optimal Collection Volume: 

4.5 mL; full tube
Minimum Volume:

2 mL
Collection Instructions:

Gently invert the sample 5-6 times after collection.
Specimen Transport:

Refrigerate
Processing Instructions: 

1. Allow sample to clot for 30 minutes.

2. Centrifuge specimen within 2 hours of collection.

3. Separate serum into a false bottom container.

4. Keep serum refrigerated until testing can be performed.

Specimen Stability

Specimen Type Temperature Time
Serum Refrigerated 7 days
Room Temperature 8 hours

 

Specimen Rejection Criteria

Hemolysis Mild OK; Moderate OK; Gross Reject
Lipemia Mild OK; Moderate OK; Gross Reject
Icterus Mild OK; Moderate OK; Gross Reject
Other Quantity not sufficient

Useful For

Used when considering a diagnosis of celiac disease. 

Methodology

Bio-Rad BioPlex 2200: Multiplex flow immunoassay

Reference Ranges

 

 Test ID   Reference Range and Reporting Units
TTGA < 15 U/mL: Negative
> 15 U/mL: Positive
GLDA < 15 U/mL: Negative
> 15 U/mL: Positive

 

Note: Reference range changed on 1/22/19. Please see the link to the January 2019 LabWire under "Resources" on this page for details.

Interpretive

CDSP - Clinical & Interpretive: Celiac Disease Serology Cascade, Serum (mayocliniclabs.com)

Day(s) Performed

Monday through Friday

Expected TAT

Same day or 1-2 days

Performing Laboratory

Bronson Laboratory, Chemistry - Kalamazoo

Sample Retention Time

7 days

CPT Code

83516 x 2

LOINC Code

  • TTGA: 46128-5
  • GLDA: 63453-5