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Test Code CCPT or LAB851 Cyclic Citrullinated Peptide (CCP) IgG, Serum

Important Note

Patient Preparation: For 12 hours before this test, do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins. Biotin can interfere with many immunoassay tests.

Specimen Requirements

Container Type:

Optimal: Gold 

Acceptable: Red
Optimal Collection Volume: 

4.5mL; full tube
Minimum Volume:

1 mL whole blood
Collection Instructions:

Gently invert the sample 5-6 times after collection.
Specimen Transport:

Refrigerate
Processing Instructions: 

1. Allow the specimen to clot for 30 minutes.

2. Centrifuge specimen within 2 hours of collection.

3. After centrifugation, specimen tubes without a gel barrier should have the serum aliquoted to a false bottom container.

4. Keep the serum refrigerated until testing can be performed.

Specimen Stability

Specimen Type Temperature Time
Serum Refrigerated 8 days
Room Temperature 3 days
Frozen 12 months

Specimen Rejection Criteria

Hemolysis Mild OK; Moderate OK; Gross Reject
Lipemia Mild OK; Moderate OK; Gross Reject
Icterus Mild OK; Moderate OK; Gross Reject
Other Quantity not sufficient

Useful For

The results of the assay are intended to be used as an aid in the diagnosis of rheumatoid arthritis in combination with other clinical and laboratory findings.

Methodology

Roche Cobas - Electrochemiluminescence immunoassay 

Reference Ranges

 Test ID   Reference Range and Reporting Units
CCPT Negative: < 17 U/mL
Positive: > 17 U/mL

 

Note: Due to inavailability of CCP reagent, the laboratory changed to a different method on 3/10/23. With the new method, the normal reference range changed from <3 to < 17 U/mL

Interpretive

A positive result for cyclic citrullinated peptide (CCP) antibodies may be suggestive of rheumatoid arthritis (RA) if compatible clinical features of disease are present.

 

Significantly elevated levels of CCP antibodies may be useful to identify RA patients with erosive joint disease.

 

Source: Mayo Medical Labs

Day(s) Performed

24/7

Expected TAT

Same day

Performing Laboratory

Bronson Laboratory, Chemistry - Kalamazoo

Sample Retention Time

7 days

CPT Code

86200

LOINC Code

33935-8

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