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Test Code BHYPS Hypersensitivity Pneumonitis Panel, Immunoglobulin G, Serum

Important Note

Effective Date 7/22/26

Test ID: BHYPS

Due to reagent issues, Aureobasidium pullulans, IgG Antibody, will not be reported. the CPT code will be updated to 86001 x 7 to reflect this change.

The presence of IgG antibodies to Aureobasidium pullulans acts as a biomarker of exposure, and it is not sufficient alone to esablish a diagnosis of hypersensitivity pneumonia (HP). In addition, the prevalence of anti-Aureobasidium pullulans IgG antibodies in patients with HP is generally low and less common than antibodies to Aspergilus fumigatus or avian antigens like pigeon. The absence of anti-Aureobasidium pullulans IgG does not limit the clinical relevance of the HP antibody panel in the evaluation of at-risk patients.

This change is expected to last approximately 6-10 months. Another update will be provided when full testing resumes.

Additional Codes

MAYO CODE
BHYPS
EPIC CODE
LAB2084
LIS CODE
FHSPP

 


Ordering Guidance


This is a panel of tests which includes serology for: Alternaria tenuis/alternata, Aspergillus fumigatus, Aureobasidium pullulans, Laceyella sacchari, Micropolyspora faeni, Penicillium chrysogenum/notatum, Phoma betae, and Trichoderma viride. If only Aspergillus fumigatus is requested, order SASP / Aspergillus fumigatus, IgG Antibodies, Serum.



Specimen Required


Container/Tube: Sarstedt Aliquot Tube, 5 mL (T914)

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL Serum

Collection Information: Centrifuge and aliquot serum into a plastic vial.


Useful For

Evaluation of patients suspected of having hypersensitivity pneumonitis induced by exposure to Alternaria tenuis/alternata, Aspergillus fumigatus, Aureobasidium pullulans, Laceyella sacchari, Micropolyspora faeni, Penicillium chrysogenum/notatum, Phoma betae, and Trichoderma viride

Reporting Name

Hypersensitivity Pneum Panel,IgG, S

Specimen Type

Serum

Specimen Minimum Volume

Serum: 0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

Alternaria alternata, IgG antibody: ≤19.0 mg/L

Aspergillus fumigatus, IgG antibody: ≤102.0 mg/L

Aureobasidium pullulans, IgG antibody: ≤16.0 mg/L

Laceyella sacchari, IgG antibody: ≤45.0 mg/L

Micropolyspora faeni, IgG antibody: ≤6.0 mg/L

Penicillium chrysogenum, IgG antibody: ≤94.0 mg/L

Phoma betae, IgG antibody: ≤16.0 mg/L

Trichoderma viride, IgG antibody: ≤16.0 mg/L

Day(s) Performed

Monday through Friday

Report Available

2 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86001 x 7

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BHYPS Hypersensitivity Pneum Panel,IgG, S 35577-6

 

Result ID Test Result Name Result LOINC Value
BH01 Alternaria alternata, IgG Ab 26951-4
BH02 Aspergillus fumigatus, IgG Ab 26954-8
BH03 Aureobasidium pullulans, IgG Ab 26955-5
BH04 Laceyella sacchari, IgG Ab 105270-3
BH05 Micropolyspora faeni, IgG Ab 26948-0
BH06 Penicillium chrysogenum, IgG Ab 26957-1
BH07 Phoma betae, IgG Ab 35551-1
BH08 Trichoderma viride, IgG Ab 49687-7
BH09 Hypersensitivity Interpretation 69048-7