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HelpTest Code ACHROM or LAB3534 Chromatin Antibody, Serum
Specimen Requirements
| Container Type: |
Optimal: Gold Acceptable: Red
|
| Optimal Collection Volume: |
4.5mL; full tube |
| Minimum Volume: |
1 mL whole blood |
| Collection Instructions: |
Gently invert the sample 5-6 times after collection. |
| Specimen Transport: |
Refrigerate |
| Processing Instructions: |
1. Allow the specimen to clot for 30 minutes. 2. Centrifuge specimen within 2 hours of collection. 3. After centrifugation, specimen tubes without a gel barrier should have the serum aliquoted to a false bottom container. 4. Keep serum refrigerated until testing can be performed. |
Specimen Stability
| Specimen Type | Temperature | Time |
|---|---|---|
|
Serum |
Refrigerated |
7 days |
|
Room Temperature |
8 hours |
Specimen Rejection Criteria
|
Hemolysis |
Mild OK; Moderate OK; Gross Reject |
|
Lipemia |
Mild OK; Moderate OK; Gross Reject |
|
Icterus |
Mild OK; Moderate OK; Gross Reject |
|
Other |
Quantity not sufficient |
Useful For
This assay is helpful as an aid in the diagnosis of systemic autoimmune diseases.
Methodology
Bio-Rad BioPlex 2200: Multiplex flow immunoassay
Reference Ranges
| Test ID |
Reference Range and Reporting Units |
|---|---|
| ACHROM |
< 1.0 AI: Negative |
|
> 1.0 AI: Positive |
AI = Antibody Index
Interpretive
Antibodies to Chromatin are associated with autoimmune diseases such as Systemic Lupus Erythematosus (SLE), Primary Sjogren's Syndrome, and Scleroderma (Systemic Sclerosis).
Day(s) Performed
Monday through Friday
Expected TAT
Same or 1-2 days
Performing Laboratory
Bronson Laboratory, Chemistry - Kalamazoo
Sample Retention Time
7 days
CPT Code
86235
LOINC Code
51775-5