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Test Code A1ALC Alpha-1-Antitrypsin Proteotype S/Z, LC-MS/MS, Serum

Important Note

This Proteotype S/Z test includes a result for Alpha 1
Antitrypsin and A1AT Proteotype S/Z, and will reflex to
A1APR(Alpha 1 Antitrypsin Phenotype)if Proteotype is discordant. Thus
if both Genotype and Phenotype are requested on the requisition, only
order the code A1ALC.

Additional Codes

 

Mayo Test ID
A1ALC
Epic Code
LAB2121
Sunquest Code
A1ALC

 

Reporting Name

A1AT Proteotype S/Z, LC-MS/MS, S

Useful For

Identification of homozygous and heterozygous S and Z proteotypes of alpha-1-antitrypsin deficiency

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
A1APR Alpha-1-Antitrypsin Phenotype, S Yes, (order A1APP) No

Testing Algorithm

If the mass spectrometry proteotype and quantitative serum level are discordant, then phenotyping will be added and performed at an additional charge.

 

For more information see Alpha-1-Antitrypsin-A Comprehensive Testing Algorithm

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1.25 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia Reject
Gross icterus OK

Reference Values

ALPHA-1-ANTITRYPSIN:

100-190 mg/dL

 

ALPHA-1-ANTITRYPSIN PROTEOTYPE:

Negative for S and Z phenotype (Non S Non Z)

Day(s) Performed

Monday, Thursday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82103

82542

82104 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
A1ALC A1AT Proteotype S/Z, LC-MS/MS, S 102082-5

 

Result ID Test Result Name Result LOINC Value
AATP Alpha-1-Antitrypsin, S 6771-0
34855 A1AT Proteotype S/Z, LC-MS/MS 49244-7

Profile Information

Test ID Reporting Name Available Separately Always Performed
A1ASZ A1AT Proteotype S/Z, LC-MS/MS No Yes
AATP Alpha-1-Antitrypsin, S Yes, (order AAT) Yes

Report Available

7 to 14 days

Forms

If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Test Request (T728) with the specimen.