Test Code 6MAMM 6-Monoacetylmorphine (6-MAM), Confirmation, Meconium
Reporting Name
6-MAM Confirmation, MUseful For
Detection of in utero drug exposure up to 5 months before birth
Method Name
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Performing Laboratory

Specimen Type
MeconiumAdvisory Information
For chain-of-custody testing, order MAMMX / 6-Monoacetylmorphine (6-MAM) Confirmation, Chain of Custody, Meconium.
Specimen Required
Supplies: Stool container, Small (Random), 4 oz (T288)
Container/Tube: Stool container (T288)
Specimen Volume: 1 g (approximately 1 teaspoon)
Collection Instructions:
1. Collect entire random meconium specimen.
2. Send specimen frozen. When refrigerated, a significant percentage of 6-MAM will convert to morphine in less than 24 hours.
Specimen Minimum Volume
0.3 g (approximately 1/4 teaspoon)
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Meconium | Frozen | 14 days |
Reject Due To
Grossly bloody | Reject |
Stool, diapers | Reject |
Reference Values
Negative
Positives are reported with a quantitative LC-MS/MS result.
Cutoff concentration:
6-MAM by LC-MS/MS: 5 ng/g
Day(s) and Time(s) Performed
Monday through Sunday; Varies
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
80356
G0480 (if appropriate)
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
6MAMM | 6-MAM Confirmation, M | 29345-6 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
31874 | 6-Monoacetylmorphine | 29345-6 |
31875 | Interpretation | 69050-3 |
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.