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Test Code NAT2O N-Acetyltransferase 2 Gene (NAT2), Full Gene Sequence, Saliva

Reporting Name

NAT2 Full Gene Sequence, Saliva

Useful For

Identifying patients who may require isoniazid dosing adjustments


Genotyping patients who prefer not to have venipuncture done

Method Name

Polymerase Chain Reaction (PCR) Followed by DNA Sequence Analysis

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type


Specimen Required

Multiple saliva genotype tests can be performed on a single specimen after a single extraction. See Multiple Saliva Genotype Tests in Special Instructions for a list of tests that can be ordered together.


Container/Tube: Oragene DNA Self-Collection Kit (T651: fees apply)

Specimen Volume: Full tube

Collection Instructions:

1. Fill tube to line.

2. Send specimen in original container per kit instructions.

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Saliva Ambient

Reject Due To

No specimen should be rejected.

Reference Values

An interpretive report will be provided.

Day(s) and Time(s) Performed


Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

81479-Unlisted molecular pathology procedure

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NAT2O NAT2 Full Gene Sequence, Saliva 90259-3


Result ID Test Result Name Result LOINC Value
NAT2S NAT2, Gene Sequencing 90259-3
32985 Haplotype 1 84414-2
32986 Haplotype 2 84414-2
32987 Haplotype 3 84414-2
32988 Haplotype 4 84414-2
32989 111T>C 82939-0
32990 190C>T 82939-0
32991 191G>A 82939-0
32992 282C>T 82939-0
32993 341T>C 82939-0
32994 364G>A 82939-0
32995 411T>A 82939-0
32996 434A>C 82939-0
32997 481C>T 82939-0
32998 499G>A 82939-0
32999 590G>A 82939-0
33000 759C>T 82939-0
33001 803A>G 82939-0
33002 845A>C 82939-0
33003 857G>A 82939-0
33004 859T>C/del 82939-0
33005 Reviewed By 18771-6
33006 NAT2 Full Gene Interpretation 69047-9

Profile Information

Test ID Reporting Name Available Separately Always Performed
NT2FO NAT2, Full Gene Sequence No Yes
NAT2S NAT2, Gene Sequencing No Yes


1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file. The following documents are available in Special Instructions:

-Informed Consent for Genetic Testing (T576)

-Informed Consent for Genetic Testing-Spanish (T826)

2. If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) form with the specimen.