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HelpTest Code KRASO KRAS Mutation Analysis, 7 Mutation Panel, Other (Non-Colorectal), Varies
Useful For
Prognostic marker for cancer patients with noncolorectal tumors treated with epidermal growth factor receptor-targeted therapies
Additional Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SLIRV | Slide Review in MG | No, (Bill Only) | Yes |
Testing Algorithm
When this test is ordered, slide review will always be performed at an additional charge.
Special Instructions
Method Name
Polymerase Chain Reaction (PCR) Analysis
Reporting Name
KRAS Mutation Analysis, OtherSpecimen Type
VariesSpecimen Required
Pathology report must accompany specimen in order for testing to be performed.
Preferred:
Specimen Type: Tissue
Container/Tube: Tissue block
Collection Instructions: Submit a formalin-fixed, paraffin-embedded tissue block.
Acceptable:
Specimen Type: Tissue
Container/Tube: Slides
Specimen Volume: 1 stained and 5 unstained
Collection Instructions: Submit 1 slide stained with hematoxylin and eosin and 5 unstained, nonbaked slides with 5-micron thick sections of the tumor tissue.
Specimen Minimum Volume
Formalin-fixed, paraffin-embedded (FFPE) tissue block (preferred) or 1 slide stained with hematoxylin and eosin and 5 unstained, nonbaked slides (5-microns thick sections) of the tumor tissue.
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Ambient (preferred) | ||
| Frozen | |||
| Refrigerated | |||
Reject Due To
| Specimens that have been decalcified (all methods) Specimens that have not been formalin-fixed, paraffin-embedded Bone marrow in EDTA | Reject |
Reference Values
An interpretive report will be provided.
Day(s) and Time(s) Performed
Monday through Friday; Varies
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
81275-KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene) (eg, carcinoma) gene analysis, variants in codons 12 and 13
Additional Test
88381-Microdissection, manual
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| KRASO | KRAS Mutation Analysis, Other | 75974-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 53279 | Result Summary | 50397-9 |
| 53280 | Result | 82939-0 |
| 53281 | Interpretation | 69047-9 |
| 53282 | Specimen | 31208-2 |
| 53283 | Source | 31208-2 |
| 54446 | Tissue ID | 80398-1 |
| 53284 | Released By | 18771-6 |
Forms
1. Molecular Genetics: Inherited Cancer Syndromes Patient Information (T519) in Special Instructions.
2. If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.