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Test Code FMSI1 Maternal Serum Screening, Integrated, Specimen #1, PAPP-A, NT

Additional Codes

Mayo Code
Sunquest Code


Specimen Required

Specimen #1 collection must occur between 10 weeks, 0 days and 13 weeks, 6 days gestation. (If gestational age is based on Crown-Rump length (CRL), the specimen must be collected when the CRL is between 32.4 - 83.9 mm)


Draw blood in a plain red-top tube(s), serum gel tube is acceptable. Spin down and send 0.5 mL serum refrigerated in a plastic vial.


Separate from cells ASAP or within 2 hours of collection.



Submit with order: Patient's date of birth, current weight, number of fetuses present, patient's race, if the patient was diabetic at the time of conception, if there is a known family history of neural tube defects, if the patient has had a previous pregnancy with a trisomy, if the patient is currently smoking, if the patient is taking valproic acid or carbamazepine (Tegretol), if this is a repeat sample, and the age of the egg donor if in vitro fertilization.

Useful For

Helpful to identify pregnancies at increased risk of having a child with Down syndrome (DS), open neural tube defects (ONTD) and trisomy 18 (T18). This test is not diagnostic.

Profile Information

Test ID Reporting Name Available Separately Always Performed
FMTPI Patient information No Yes
FMIN1 Maternal Screen INT-1 No Yes

Method Name

Quantitative Chemiluminescent Immunoassay

Reporting Name

Maternal Serum Screen INT, Sp-1

Specimen Type


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  90 days
  Ambient  72 hours

Reject Due To

Hemolysis Mild reject/Gross reject
Lipemia NA
Icterus NA
Other Plasma

Reference Values

An interpretive report will be provided.


Part 2 must be completed in order to receive an interpretable result.


If the second specimen is not received for sequential screening, the results are uninterpretable and no maternal risk will be provided.

Day(s) and Time(s) Performed

Sunday - Saturday

Performing Laboratory

ARUP Laboratories

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
FMSS1 Maternal Serum Screen INT, Sp-1 Not Provided


Result ID Test Result Name Result LOINC Value
Z5147 Nuchal Translucency (NT) 12146-7
Z5148 Nuchal Translucency (NT), Twin B 12146-7
Z5149 Maternal Screen Interpretation 49586-1
Z5150 Maternal Age At Delivery 21612-7
Z5151 Maternal Weight 29463-7
Z5152 Estimated Due Date 11778-8
Z5153 Gestational Age Calculated at Coll. 18185-9
Z5154 Dating 21299-3
Z5155 Number of Fetuses 11878-6
Z5156 Maternal Race 21484-1
Z5157 Smoking 64234-8
Z5158 Family History of Aneuploidy 32435-0
Z5159 Specimen 19151-0
Z5160 Crown Rump Length 11957-8
Z5161 Crown Rump Lenth, Twin B 11957-8
Z5162 Sonographer Certification Number 49089-6
Z5163 Sonographer Name 49088-8
Z5164 Ultrasound Date 34970-4
Z5165 Best date to draw sample nmb 2 by 33882-2
Z5166 EER Maternal Serum, Integrated, Sp1 11526-1
Z5146 PAPP-A Maternal 48407-1