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Test Code EEEVP Red Blood Cell (RBC) Enzyme Evaluation

Reporting Name

RBC Enzyme Evaluation

Useful For

Identifying defects of red cell enzyme metabolism


Evaluating patients with hemolytic anemia

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
GLTI Glutathione, B No No
RBCE Reflexed RBC Enzymes No No

Testing Algorithm

This is a consultative evaluation in which the case will be evaluated at Mayo Clinic Laboratories, the appropriate tests performed at an additional charge, and the results interpreted.

Note: RBCE / Reflexed RBC Enzymes, Blood includes: adenylate kinase, phosphofructokinase, phosphoglycerate kinase, triosephosphate isomerase, and pyrimidine 5'nucleotidase.


See Benign Hematology Evaluation Comparison in Special Instructions.

Method Name

EEEV: Consultative Interpretation

G6PD, GPI, PK, GLTI, HEXK, RBCE: Kinetic Spectrophotometry (KS)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Whole Blood ACD-B

Specimen Required

Container/Tube: Yellow top (ACD solution B)

Specimen Volume: 12 mL

Collection Instructions: Do not transfer blood to other containers.

Specimen Minimum Volume

5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood ACD-B Refrigerated 8 days

Reject Due To

Gross hemolysis Reject

Reference Values

Definitive results and an interpretive report will be provided.

Day(s) and Time(s) Performed

Monday through Friday; Varies

Test Classification

See Individual Test IDs

CPT Code Information


84087-Glucose phosphate isomerase

84220-Pyruvate kinase


82978-Glutathione (if appropriate)

83915-RBC Enzymes (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
EEEVP RBC Enzyme Evaluation In Process


Result ID Test Result Name Result LOINC Value
21065 Erythrocyte Enzyme Interpretation 59466-3
G6PD_ G-6-PD, QN, RBC 32546-4
GPI_ Glucose Phosphate Isomerase, B 44050-3
HEXK_ Hexokinase, B 49216-5
PK_ Pyruvate Kinase, RBC 32552-2

Profile Information

Test ID Reporting Name Available Separately Always Performed
EEEV Erythrocyte Enzyme Interpretation No Yes
G6PD G-6-PD, QN, RBC Yes Yes
PK Pyruvate Kinase, RBC Yes Yes
GPI Glucose Phosphate Isomerase, B Yes Yes
HEXK Hexokinase, B No Yes


1. Metabolic Hematology Patient Information (T810) is available in Special Instructions

2. If not ordering electronically, complete, print, and send a Benign Hematology Test Request Form (T755) with the specimen.