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Test Code CRPHS C-Reactive Protein, High Sensitivity, Serum or Plasma

Important Note

High Sensitivity CRP  (CRPHS)  is a measurement of CRP at very low levels.   CRPHS is more precise than standard CRP when measuring baseline (ie, normal) concentrations and enables a measure of chronic inflammation.

Atherosclerosis is an inflammatory disease and hs-CRP has been endorsed by multiple guidelines as a biomarker of atherosclerotic cardiovascular disease risk.(European 2011, Goff 2013, Jacobson 2014).   This hs-CRP assay should be used as a means to assess risk of cardiovascular disease or events. A different CRP test (C-Reactive Protein “CRP”)  should be used to monitor or assess other inflammatory disorders.

Additional Codes

Epic Order Code: LAB150
Sunquest Order Code: CRPHS

Specimen Required

Container Type:


Inpatient: Mint

STAT: Mint

Outpatient: Gold 

Acceptable: Red Top or Green Lithium Heparin.


Optimal Collection Volume: 

A full tube is optimal for all blood draws.  Not only does it give the correct ratio of anticoagulant or clot activator to blood, a full tube allows for efficient automated testing and provides residual sample for any repeat, add on or reflex tests.   Please note: In most cases, multiple test orders requiring the same tube type may be combined in one tube.   Do not draw a separate tube for each test.   For exceptions where a test has a larger sample volume requirement, it will be noted in this section.


The approximate volume of blood needed for this test is 1.0 mL of blood (0.5 ml of serum or plasma).

Collection Instructions:

Gently invert sample 5-6 times after collection.

Processing Instructions: 

1. Allow serum sample to clot for 30 minutes.

2. Centrifuge specimen within 2 hours of collection.

3. Specimen tubes without a gel barrier should have the serum or plasma aliquoted to a false bottom container after centrifugation.

4. Keep serum/plasma refrigerated until testing can be performed.

Useful For

This assay is useful in assessing the risk of cardiovascular disease.

Method Name


Stability Information

Specimen Type Temperature Time
Serum* Refrigerated 8 days
  Ambient  3 days
  Frozen  3 years

*Note: Heparinized plasma in gel separator tubes is less stable than serum and is only suitable for add-on testing up to 2 days following sample collection. 

Rejection Due To

Hemolysis Mild OK; Moderate OK; Gross Reject
Lipemia Mild OK; Moderate OK; Gross Reject
Icterus Mild OK; Moderate OK; Gross Reject
Other N/A


Post Processing Specimen Type

Preferred: Serum

Alternate: Plasma

Specimen Minimum Volume

Collecting minimum volumes can result in a need for sample recollection, and/or a delay in results. Minimum volumes are subjective and cannot account for all aspects of specimen and testing needs. Refer to the Specimen Required section for optimal volumes for laboratory specimens. Contact the Bronson Laboratory if complex collection exceptions occur that require more information.


Minimum Volume: 0.5 mL whole blood, 0.25 mL serum or plasma
Neonate Volume: 1 microtainer (400-600 uL)

Performing Laboratory

Bronson Laboratory, Chemistry - Kalamazoo

Day(s) Performed


Reference Values

 Test ID   Reference Range    Units      
CRPHS <1 (below average cardiac risk) mg/L
  1-3 (average cardiac risk) mg/L
  >3 (increased cardiac risk) mg/L
  >10 (investigate for non-cardiac source of infection or inflammation) mg/L

LOINC Code Information


CPT Code Information


Sample Retention Time

7 days