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Test Code APCRR Activated Protein C Resistance Ratio

Additional Codes

Epic Order Code: LAB3496
Sunquest Order Code: APCRR


Specimen Required

Container Type:

1.8 mL or 2.7 mL blue top tube:

Optimal Collection Volume: 

2.7 mL in solid blue top tube or 1.8 mL in clear blue top tube.  Minimum volume is indicated by the etched line on the tube.

Collection Instructions:
  1. Gently invert 5 to 10 times to mix blood.
  2. If collected through a blood collection set (butterfly), a discard tube must first be drawn to eliminate dead space from tubing.  
Processing Instructions: 

1. Centrifuge sample within 4 hours of collection.  Platelet poor plasma must be obtained per laboratory procedure.

2. If testing will be delayed >4 hours from collection, aliquot plasma into separate vial and freeze immediately.

Useful For

Evaluation of patients with incident or recurrent venous thromboembolism (VTE).

Evaluation of individuals with a family history of VTE.

Profile Information

Test ID Reporting Name Available Separately Always Performed
APCRR APC Resistance Ratio Y Y

Method Name

Optical clot based assay

Stability Information

Specimen Type Temperature Time
Whole blood Ambient 4 hours
Platelet Poor Plasma Ambient  4 hours
Platelet Poor Plasma Frozen  18 months

Rejection Due To

Hemolysis Hemoglobin up to 500 mg/dL
Lipemia Triglycerides up to 1791 mg/dL
Icterus Bilirubin up to 18.8 mg/dL


Specimen Minimum Volume

Refer to the Specimen Required section for optimal volumes for laboratory specimens. Contact the Bronson Laboratory if complex collection exceptions occur that require more information.

Minimum Volume: 1.8 mL in clear light blue top tube
Neonate Volume: 1.8 mL in clear light blue top tube

Performing Laboratory

Bronson Laboratory, Coagulation - Kalamazoo

Day(s) and Time(s) Performed

Testing performed Monday/Wednesday/Friday 0800-1200

Reference Values

Test ID Reference Range
APCRR ≥ 2.26

LOINC Code Information


CPT Code Information


Sample Retention Time

Ambient samples 24 hours
Frozen samples 1 month